Health economic modelling is commonly used to assess the cost-effectiveness of anti-osteoporosis interventions. Modelling an intervention requires an assumption about the effects of treatment after discontinuation (a period called ‘offset time’). This study aims to review the effects of anti-osteoporosis treatments after discontinuation, to assess the impact of different offset time assumptions on the cost-effectiveness of osteoporosis medications and to discuss some recommendations and challenges regarding offset time. Several studies have studied the effects after discontinuation of osteoporosis medications, suggesting a different effect between drug options and that further investigation would be needed, given evidence remains limited. Offset time has been shown to be a critical component of health economic modelling in osteoporosis, that could markedly influence the cost-effectiveness of osteoporosis treatment. It is therefore essential to carefully define offset time and to systematically conduct sufficient sensitivity analyses on offset time.
Effect of offset time on the cost-effectiveness of osteoporosis medications
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Published on January 31th, 2019
