Osteoporosis is an increasingly major health problem around the world (1). It is a disease characterized by low bone mass with microarchitectural disruption and increased skeletal fragility, leading to increased fracture risk. Worldwide, at least 1 in 3 women and 1 in 5 men will suffer from an osteoporotic fracture during their remaining lifetime (2). Osteoporotic fractures result in significant morbidity, mortality, and reductions in quality of life (3, 4), and are associated with an increased risk of subsequent fractures (5, 6). They also impose a huge financial burden on health-care systems (1). With an aging population and increasing life expectancy, their consequences are expected to further increase in the future.
